Fishing in the Bay

4 July 2022

NSSS

This article described the difficulties in providing required sample sizes for clinical trials that guarantee type 1 and type 2 error control. Quoted sample sizes should be based on an efficient and exact test, and the so-called E-test is chosen for this purpose. To compute exact sample sizes in real time is not currently feasible so a corpus of pre-computed powers (and sizes) has been created, covering sample sizes up to 500. When there are no solutions within the corpus, a novel extrapolation technique is used. All the code has been converted into an R-package which is illustrated.

This article described the difficulties in providing required sample sizes for clinical trials that guarantee type 1 and type 2 error control. Quoted sample sizes should be based on an efficient and exact test, and the so-called E-test is chosen for this purpose. To compute exact sample sizes in real time is not currently feasible so a corpus of pre-computed powers (and sizes) has been created, covering sample sizes up to 500. When there are no solutions within the corpus, a novel extrapolation technique is used. All the code has been converted into an R-package which is illustrated.

This article described the difficulties in providing required sample sizes for clinical trials that guarantee type 1 and type 2 error control. Quoted sample sizes should be based on an efficient and exact test, and the so-called E-test is chosen for this purpose. To compute exact sample sizes in real time is not currently feasible so a corpus of pre-computed powers (and sizes) has been created, covering sample sizes up to 500. When there are no solutions within the corpus, a novel extrapolation technique is used. All the code has been converted into an R-package which is illustrated.

This article described the difficulties in providing required sample sizes for clinical trials that guarantee type 1 and type 2 error control. Quoted sample sizes should be based on an efficient and exact test, and the so-called E-test is chosen for this purpose. To compute exact sample sizes in real time is not currently feasible so a corpus of pre-computed powers (and sizes) has been created, covering sample sizes up to 500. When there are no solutions within the corpus, a novel extrapolation technique is used. All the code has been converted into an R-package which is illustrated.

This article described the difficulties in providing required sample sizes for clinical trials that guarantee type 1 and type 2 error control. Quoted sample sizes should be based on an efficient and exact test, and the so-called E-test is chosen for this purpose. To compute exact sample sizes in real time is not currently feasible so a corpus of pre-computed powers (and sizes) has been created, covering sample sizes up to 500. When there are no solutions within the corpus, a novel extrapolation technique is used. All the code has been converted into an R-package which is illustrated.