All Fishing in the Bay Blog Posts

NSSS

4 July 2022

This article described the difficulties in providing required sample sizes for clinical trials that guarantee type 1 and type 2 error control. Quoted sample sizes should be based on an efficient and exact test, and the so-called E-test is chosen for this purpose. To compute exact sample sizes in real time is not currently feasible so a corpus of pre-computed powers (and sizes) has been created, covering sample sizes up to 500. When there are no solutions within the corpus, a novel extrapolation technique is used. All the code has been converted into an R-package which is illustrated.

This article described the difficulties in providing required sample sizes for clinical trials that guarantee type 1 and type 2 error control. Quoted sample sizes should be based on an efficient and exact test, and the so-called E-test is chosen for this purpose. To compute exact sample sizes in real time is not currently feasible so a corpus of pre-computed powers (and sizes) has been created, covering sample sizes up to 500. When there are no solutions within the corpus, a novel extrapolation technique is used. All the code has been converted into an R-package which is illustrated.

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The Case of the Fatal Ratio

28 March 2022

We can all limit our chance of getting Covid. If we get vaccinated and follow the advice about masks and physical distancing, the chance will be much lower. What you and I cannot control is our chance of dying if we get infected. The concept of the case fatality rate (CFR) is apparently straight-forward. If I get infected what is the chance that I die? That’s the bottom line surely.

How would we estimate this? By a simple ratio. How many of those infected say one month ago ended up dying? A kid in grade 4 could understand it. When I went to school, we could have calculated it using long-division. Alas, no longer…

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